Guest host: Lee Cowan. In our cover story, Susan Spencer examines the impact that Ozempic and other GLP-1 medications are having on Americans' weight. Also: Lee Cowan talks with Sharon Stone about her art; Tracy Smith sits down with actress Emma Stone and director Yorgos Lanthimos to discuss their latest collaboration, "Poor Things"; Ted Koppel profiles Episcopal Bishop Gene Robinson, who in 2003 became the first openly-gay bishop; Conor Knighton explores ancient earthworks in Ohio that are now a UNESCO World Heritage Site; Dr. Jon LaPook offers insight into the prostate and diagnoses of prostate cancer; and David Pogue visits a striking photography exhibition where the images are created out of the residue on the bottom of whiskey glasses.

Jane Pauley hosts our annual "Food Issue," devoted to all things epicurean. Among our delicious features: David Pogue visits a laboratory that helps launch new food trends; Lee Cowan samples Texas BBQ with a foreign flavor, while Seth Doane checks out a traditional Sardinian flatbread being exported around the world; Tracy Smith visits the Chicago sandwich shop that inspired "The Bear"; Luke Burbank explores the popularity of tinned fish; Jane Pauley interviews Garth Brooks, who is opening a bar & honky-tonk in Nashville; Faith Salie talks with Pinky Cole, founder of the Slutty Vegan fast food chain; Kelefa Sanneh gets in the kitchen with New York Times food columnist Melissa Clark; Jonathan Vigliotti checks out a California baker who specializes in bouza, a traditional Syrian ice cream; and Serena Altschul looks at some tools of the culinary trade.