Suzi is thrown in at the deep end, dealing with serious emergencies in A&E. Adam feels that he is not hands-on enough with patients and is frustrated by paperwork, while Lucy has to do her first rectal examination.

The junior doctors have to face up to the fact that they can't save everyone, as Jon responds to an emergency crash call and Lucy struggles with her emotions after having to tell a patient their condition is terminal. Katherine is on her first set of night shifts.

Jon's social life may be affecting his work. Keir faces a big decision about his future.

Suzi's bedside manner is put to the test when she treats a patient who has a toilet brush stuck up his bottom. With teamwork critical, can Andy bond with the staff on the children's ward?

How will Adam cope on his first night shifts, can Suzi regain her confidence, and will Kier and Katherine's patient pull through his operation?

How will Suzi and the A&E team cope as the department is moved overnight to a brand new ward? And as the junior doctors prepare for their next placements, do they feel they are up to the job?