Gary Busey, Donna D'Errico, Toccara Jones, Jenna Morasca, and Hal Sparks visit the Waverly Hills Sanatorium in Louisville, Kentucky, to investigate ghost sightings. The abandoned hospital, built to house tuberculosis patients and reportedly the site of thousands of deaths, is considered to be one of the most haunted hospitals in the United States.

Rachel Hunter, Ethan Zohn, Godfrey, Tony Little, and Traci Bingham investigate the paranormal at a haunted Connecticut asylum. It is the site of mental patient Nell Marley's suicide, supposedly as a result of her possession by a spirit named Pearl.

Mariel Hemingway, Joe Piscopo, Michael Bergin, Picabo Street, and Tonya Cooley investigate a facility known as "The Walls," a haunted maximum security prison in the south, where warden Tom Grisholm was murdered by an inmate.