Beth discovers that her boyfriend Paul is the new boss at the hospital, but isn't so happy when he gives her and the doctors an unexpected shake-up. Callum is floundering among his testosterone-fuelled colleagues and makes a deadly mistake. Meanwhile, Kate is horrified when Beth makes a play for Jamie, and goes to extreme measures in an effort to dump Ray. And in a bid to become Leeds' answer to Carrie Bradshaw, Anji decides to write an article about her sex life. Her attempt at a threesome is a terrible let-down, but she can still use her imagination...

Beth finally finds herself a wealthy man, complete with good job, platinum credit card and sports car. He doesn't even bore her to tears, but a troublesome patient stops her in her tracks. Callum and Anji bridge the doctor-nurse divide, striking up an improbable friendship. And, sick of playing mum in the house, Kate ignores the housework and goes on a shopping spree...

As her wedding to Peter approaches, Kate takes him to visit what could be their dream home in the country, but he doesn't seem overly impressed. Anji proudly shows off her new baby, but still hasn't made up with Callum, who is avoiding her in the hospital. Beth and Rob are getting on brilliantly and already seem like they've been a couple for ages. Meanwhile, unhappy Lia sees everyone else around her moving on. Emma can tell her mum hasn't been happy since Jamie left and tries to convince her that a trip to Australia may be just the tonic

Work and motherhood clash for Lia when her daughter Emma's father announces that he plans to move away and take Emma with him. Lia finds it easier to play supernurse than supermum... Back at St Margaret's, Anji solves a medical mystery and Beth plays a mischievous game with an ambulance chaser. Kate returns to the ward following her anger management course, and the girls are highly amused to discover that Beth fakes her orgasms... to the tune of Celine Dion.

Anji may be set on an arranged marriage, and sex-kitten Beth has yet to meet the rich consultant of her dreams, but that doesn't stop them hunting down any other man they fancy in the meantime. Sharp-tongued and funny single mum Lia is a great nurse but a lousy mother, and lovely Kate, the acting sister on the male-dominated Medical Assessment Unit, would cope better with the sexual politics if she remembered that doctors are the enemy, instead of falling for them... In this episode, Kate's out-of-character one night stand with handsome doctor Jamie has terrible consequences on the ward, while minxy Beth teaches young Callum that doctor doesn't always know best.

Kate has started a new Nurse Practitioner course and is full of fresh ideas for the ward. So when a suspected case of anthrax walks through the door she takes charge and puts her staff in quarantine. Beth is still convinced nurse Justyn tricked her about his sexuality just to get her into bed. So in true Beth fashion she plans revenge and plays a trick of her own. Anji turns up to work an hour and a half late after a champagne breakfast, a patient susses that she has been drinking and Kate has no choice but to take disciplinary action against her friend. Then, to the surprise and horror of her three friends, Anji quits her job.

After quitting her job at the hospital, Anji has taken the plunge and decided to go travelling around India. Beth is anxious about what life will be like without her: she secretly worries that Anji is the only reason that Lia and Kate are friends with her. And then she catches the two of them having an impromptu drink in the pub without her... Back on the ward, Dr Callum is jealous of nurse Justyn's popularity with the patients. When he discovers this is down to Justyn's 'professional campness', he persuades Justyn to teach him the basics.

A new addition to the ward, registrar and ex-army doctor Peter Compton, gets a welcome he won't forget when all the guests at a wedding reception turn up at MAU with a nasty case of food poisoning. Dr McManus's reputation as a basket case and his increasingly strange behaviour worry Peter. Kate defends McManus and sets about trying to work out what's the cause of his erratic outbursts. In an attempt to build bridges with Peter, Kate finds herself on an unconventional Friday night "business meeting", but is his interest in her on more than just a professional level? Lia is dismayed to discover that Jamie has been offered a job in Australia. Can he muster the courage to accept the job? Will she agree to go with him? Could she bear to leave her daughter behind? Callum volunteers to take part in overnight clinical trials for a mystery drug. When Beth finds out how much money he is making, she and Justyn decide to join him. But they can't understand why they are suffering adverse symptoms while Callum is smugly acting as normal...