A millionaire, his wife, and their daughter are all found shot to death in their California home. With a long list of potential suspects, investigators spend three years analyzing every piece of the puzzle and make an arrest that shocks everyone.

In May 2004, three matching suitcases containing male body parts surface off the coast of Virginia Beach. Investigators gather circumstantial against the victim's wife, but now they must prove she is capable of the gruesome murder of her husband.

For eight years, the Bike Path Killer terrorized women in the Buffalo area - committing seven rapes and two murders. Then, without explanation, the attacks stopped. After a 12-year absence, the Bike Path Rapist resurfaces.

Salt Lake City is rocked by a series of package bombings leaving two people dead. The third victim, Mark Hofmann, a rare documents dealer, survives the bombing. But the story he tells investigators, doesn't jive with what explosives experts know.

In 2001, 20-year old ranger Carrie Nelson is found beaten to death in a park office. The senseless killing turns into a five year long whodunit. Investigators turn to science as they track down an elusive and unlikely killer.

Dana Satterfield is found strangled to death in the back room of her beauty salon. A solid alibi clears Dana's husband of any suspicion. But, as other leads are exhausted, the case turns cold -- until an individual comes forward with a dark secret.

In March of 2004, a man reports his wife missing, within a few hours police discover her dead body in an abandoned vehicle. Meanwhile, a serial killer letter admits responsibility for the murder, but the evidence suggests otherwise.

In 2008, 16-year old Meghan Landowski is found stabbed to death. A seemingly open and shut case turns into a months' long whodunit. Police methodically eliminate suspects in their hunt for a young girl's killer.

In Bellevue, Idaho, a 16-year-old girl runs into her neighbor's home exclaiming an intruder has shot her parents. She claims she did not see the intruder and has no clue as to who would want them dead.

After David Castor is found dead from poisoning, his wife and stepdaughter are both suspected of crafting the murder plot. The investigation takes an unexpected twist when one suspect attempts to kill the other.

A woman is found murdered in her home. Police suspect the husband because there is no sign of forced entry. Six months into their investigation, detectives get a surprise tip that blows the case wide open.

A suburban Oklahoma town is rocked by the brutal stabbing murder of 27-year-old Gary Larson and the rape of his girlfriend. The attacker leaves a trail of bloody footprints in Larson's house and investigators must follow the footsteps to catch the killer.

One morning, a church employee arrives to work and trips on a woman's body. The pastor of the church suspects it could have been a random killing. Further questioning leads detectives to suspect another member of the church.

In 1980, Karin Strom is found strangled to death. A seemingly open and shut case turns into a 26-year whodunit. DNA taken from three prime suspects is compared to DNA recovered from the victim. The results are startling.

The murder of family man Ronald Whitehead is disguised as a carjacking. A long trail of clues leads detectives back to Ronald's doorstep with a member of his family suspected of masterminding the killing.

Caught on surveillance video, Rhonda Ward-Goodwin is seen forced into her car by an unknown man and driven away. With little evidence, detectives do not have much to go on, until Rhonda's car is found engulfed in flames a week later.

Human remains found in a sewer are identified as Tristan Jensen, a 14-year-old boy who was reported missing. Investigators find it hard to believe that another teenager could be the prime suspect in one of the most gruesome murders they have ever seen.

On the case of the murder of a young woman, police discover a clue on the wall near her lifeless body. Investigators identify the word "Roc" and they must determine whether or not she wrote it herself or if someone else was responsible.

25-year-old waitress Corey Parker is found dead in her apartment bedroom with over 100 stab wounds to her body. After two long years of intense investigation, detectives finally zero in on a suspect. But the crafty killer knows he's being watched.

A prominent Tucson pediatric ophthalmologist is found murdered in the parking lot of his office. Investigators focus on his former partner who claimed the doctor was stealing patients from his practice.