Grandpa Libero has finally returned to Poggio Fiorito. Immediately, Marco and Maria announce their wedding, which will take place in two weeks. For the occasion, Grandpa has a special surprise in store: he's hiring Al Bano! The offer to buy the Aurora clinic forces Lele to tell the truth about the house they're about to take from him. The Martini family, informed, takes action.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

While Lele and Irene visit the stalls of the neighborhood party where even Libero, Giulio and Giacinto sell modern objects, the Martini house catches fire.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground, after being run over. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of the girl's identity.

Lorenzo manages to operate on a little girl with a heart malformation with his own. Celeste and Lorenzo are very happy and compliment each other. They leave the clinic together hand in hand, but Sara catches them in the act.

Made aware of the crisis with Lorenzo, Libero goes to the cottage to talk to Sara. The girl shows Libero a nearby grove but just then some gardeners from the Municipality arrive: the trees have to be cut down.

Knowing the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to despair and gets drunk. Meanwhile, the financiers of the new surgery department arrive at the clinic, which will be directed by Lorenzo.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground after being hit. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of her identity. It's the day of the volleyball tournament final. The boys are excited and thrilled, but they realize their coach is distracted and has other things on her mind. Meanwhile, Lorenzo receives a bitter message from Sara.

Having learned of Lorenzo's crisis, Libero goes to the house to speak with Sara. She shows Libero a nearby grove, but just then, city gardeners arrive: the trees need to be cut down. Maddalena, deeply concerned about Rocco's situation, decides to go look for him. Libero accompanies her, but when they arrive at the address Maddalena indicated, they find a crowd of people at the door and an ambulance.

Anna is increasingly struggling and has failed her entrance exam. Lele asks Carla to have Anna register for the Biology exam, which, once passed, will allow her to enter medical school. Anna, on the eve of her exam, is spending the night at a nightclub. Tommy and Agnese, who told their parents they were going to a film screening organized by the school, are at the abandoned factory.

Libero and Enrica invite Valerio to dinner to repay him. For this reason, Lele is forced to reveal the secret that binds him to the man. Meanwhile, Lorenzo hires Andrea to renovate his new house; when Sara meets him, she remembers the wild night she spent with him. Libero, still reeling from the revelation about Valerio, tries to attack the man, urging him to stay away from Anna. Meanwhile, Emiliano, at the suggestion of Ginevra, his new girlfriend, goes to Lele's clinic to hand over some money he owes to the young Martini, thus breaking all ties with the past.

Lorenzo decides to speak to Dr. Savino himself, but he is hiding behind professional secrecy. The last beach remains Oscar, from which he manages to discover the truth and the disease Sara suffers from.

Lorenzo remained in Poggiofiorito to assist his uncle, who faked a broken leg hoping that something would arise between him and Sara. One night, however, the young man dreams of being in a place and, with him.

Giada and Tommy decide to flee and get away from everyone. Maria and Marco, having discovered everything, decide to go and look for them with the help of Lorenzo and Veronica.

Lorenzo and Veronica continue to meet secretly in the hotel. This is where Sara arrives, warning them that Fabio is on the way. In order not to arouse suspicion, Sara kisses Lorenzo and the two pretend to be engaged.

Stefano takes Sara to the clinic, where Oscar tells her that her heart is failing and the only solution is to be admitted immediately for surgery. She decides not to tell Lorenzo. Lorenzo decides to speak to Dr. Savino himself, but he hides behind a medical confidentiality pact. Oscar remains her last resort, and from him she manages to uncover the truth and the illness Sara is suffering from.

Fiamma is forced to reveal the truth, saying that nothing happened between her and Marco; he was drunk and kept repeating Maria's name. The two, therefore, make peace...for now. Giada and Tommy decide to run away and escape from everyone. Maria and Marco, having discovered everything, decide to go look for them with the help of Lorenzo and Veronica.

A newspaper reports that Marco and a certain Fiamma, an athlete and acquaintance of Sara's, are having a romantic relationship. Maria discovers this, but her husband assures her it's just a journalistic invention. Could it be true? Stefano and Sara spend the night together, but nothing happens between them. However, the young man makes a mistake and finds himself in the living room of the Martini family, with the entire family. He finally gets to meet them!

Sara begins managing the new bar across the street from Casa Martini. On the opening morning, however, a young manager from a chain of aperitif bars, Stefano, shows up and wants to take over the place. Sara is robbed at the bar by two men blackmailing Giada. Lorenzo finds Sara unconscious on the floor and calls an ambulance. At the clinic, the young woman wakes up and learns from Lorenzo that she should have a CT scan.

Everything seems to turn out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's broadcast, while Maria, after having clarified her doubts, will go back to Marco. And Roberto?

While Maria is in the car to join her daughter at the campsite, her car breaks down. So she decides to call Roberto, but just at that moment Marco arrives and offers to accompany her.

Marco is in danger of losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated in this way, because now Marco and Maria are forced to organize a fake wedding.

Inge, seeing her father increasingly sad, decides to arrange a meeting with the estranged mother of a schoolmate of hers. However, the appointment falls apart and the woman suffers from anaphylactic shock.

Everything seems to be working out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's show, while Maria, after clarifying her doubts, will return to Marco. And Roberto? As they're about to cut off the electricity and gas at the Martini house, the family decides to leave before it all ends before their eyes. But there's still time to plan a surprise wedding for Maria.

Marco risks losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated, because now Marco and Maria are forced to organize a fake wedding. With the help of their family, Marco and Maria manage to convince the assistant. Everything could be resolved, if it weren't for Micol's threat: if the wedding doesn't happen, she will do anything to get the child back.

Maria has no idea where Marco is, so she takes it upon herself to authorize the operation for little Jonathan. She discovers the bitter truth: Marco has been lying to her, continuing to film documentaries in war zones. Marco returns to Rome, and Maria is waiting for him at the airport, only to tell him that it's finally over between them. Once they both return home, the situation seems to improve: but how long will it last?

Bianca's relationship with her mother deteriorates under the chagrined eyes of Inge, who is truly devoted to her grandmother. Meanwhile, Marco lies to Maria about his new assignment. As if they weren't already in enough trouble, the Martinis have to renovate the roof of their house. It's not exactly the right time financially, and the family is truly worried.

The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.

Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.

Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.

For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.

Like the baron in the trees, Inge decides to run away from home, just on the day Bianca is busy baking a birthday cake for Maria. The search begins. The search continues, and Gus finally finds his daughter at the farmhouse, suggesting she travel with him to Los Angeles. At the baby's first ultrasound, Lele and Bianca discover that Ciccio and Tracy are also pregnant.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he wants to propose a TV show. Both the clinic and the company that produced the drug are reported by the brother of the patient they were treating. Meanwhile, Marco and Maria discover that they truly like each other.

Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: she's taken in a homeless man who leaves the whole family stunned. The Martinis' Christmas dinner is, as always, a seaport. And this year, on the day when everyone is at their best, Lele will give Gus a break.

Lele teaches a lesson on the environment at Annuccia's school and becomes a hit with his daughter's classmates. Meanwhile, Bianca's ex-husband, trying to put a spoke in her wheels, is determined to win over little Inge by any means necessary. A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and fearful for the future, she finds herself weighing her ex-husband Gus's offer. Meanwhile, Grandma Enrica plots to bring Maria and Marco closer together.

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The Martini family organizes a surprise birthday party for Lele, who is desperate for the woman he loves. Ciccio learns that Tracy has returned to Rome. He can't resist: he goes to visit her at the riding stables! Guido confesses his betrayal to his wife, who packs her bags and goes to live alone with her daughter, driving Guido into despair. Ciccio realizes he's in love with Tracy. Meanwhile, Lele goes to London and declares his love for Bianca.

Fanny decides to introduce Lele to her family. Ave receives permission from the Martinis to move into their home, as the housekeeper Melina is unable to care for the baby alone. Bianca receives a commission from the Vatican to make a chocolate sculpture, but the twins smash it to pieces. Lele helps Bianca, and after working all night, the two kiss.

Grandpa Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she's truly in love. Giulio convinces Grandpa Libero to participate in a new program, Cambio Nonno (Grandpa Change). Libero accepts and finds himself with a new family, one from Lazio, to boot. Consequently, the grandfather of that family goes to live with the Martinis.

Fanny and Maria become friends, but Maria is jealous because she fears Fanny is courting Guido. She doesn't suspect that her young colleague is interested in another member of her family: her father. Maria's pregnancy progresses, and so do the cravings. Meanwhile, a child neuropsychiatry department will be opened at the clinic, which is precisely the young doctor's specialty.

Maria falls ill with mumps and can no longer discuss the thesis to prevent the girl from waiting another three months, since she can't wait to go back to Africa to see Guido. To resolve the situation, the family makes a plan.

Sarita and Emilio have to keep the intrusiveness of their respective families at bay: Enrica would like to organize a big wedding, while Kabir a traditional Indian party.

At the outpatient clinic they are all gathered to wait for the announcement of who will be fired, but everyone is amazed to read that Emilio has resigned to save his colleagues.

Alberto discovers that chemotherapy has not had the desired effect on his father. However, the boy decides to indulge him in the desire to live peacefully the time that remains to him. Cettina asks the Martinis for hospitality.

To save the clinic, Emilio proposes to buy it with his colleagues and patients, all of whom will own a small share. Meanwhile, bachelor and bachelorette parties are being planned for the future spouses. At the Indian restaurant, Ravi's arrival causes a stir, especially since Kabir doesn't have the courage to reveal that his niece will soon be marrying Emilio. As if that weren't enough, the young man shows up at the clinic to see Sarita.

Ciccio and Miranda decide to run away and take refuge in a farmhouse in the countryside, owned by the parents of a mutual friend. Everyone is worried, but thanks to little Eros's intuition, Grandpa Libero knows where to look. At the outpatient clinic, everyone is gathered waiting for the announcement of who will be fired, but everyone is shocked to learn that Emilio has submitted his resignation to save his colleagues.

After being summoned by his fiancée's father, Emilio must return to Turin permanently. During dinner with Sarita, the two believe they will never see each other again, and so, with a kiss, passion ignites. Emilio declares his love for Sarita, but she fears they will end up hurting each other. Meanwhile, Torellhonor appears to be bankrupt, while Maria decides to apply for a job as a waitress at an Indian restaurant.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido is seeking funding for the family hospital and decides to organize a charity match to raise funds, while also offering a donation to the bank. After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. She also tells her that she's confused and doesn't know what she's feeling right now.

A man very similar to Grandpa Libero has been wandering around the Martini house for a few days, and trouble begins for Grandpa: everyone is starting to think he's seriously getting old and can't remember things. After a check-up recommended by Enrica, Grandpa Libero learned that his blood pressure isn't good and that he might need open-heart surgery.

Cettina doesn't know how to tell Torello that she's not actually pregnant because he's showering her with attention, arranging everything for the future baby. During an ultrasound, she steals a video showing triplets to play along. Libero is worried about Olindo, an old friend of his who's been missing for days. He learns that he's in a nursing home and can't even talk to him or find out how he's doing. Libero then asks Guido to do an inspection.

Cettina and Torello's house is now finished, but Cettina is in for some unpleasant surprises. Maria and Guido have decided to move in together, and to keep them from moving far away, Cettina finds an unexpected solution. The family decides to give Guido and Maria a hot tub and a Bohemian crystal chandelier, but the children get angry because they want to furnish the house themselves. The first arguments arise.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

After their kiss at the zoo, Guido realizes he has strong feelings for Maria, but she wants him to leave Carlotta first. Meanwhile, Carlotta seems increasingly attached to Marcello, and not just for work. Maria is tired of waiting for Guido and decides to go out and distract herself with Reby. During a night out, she's stopped by the police and her car is confiscated. Who will get her out of this mess?

Maria is preparing for an exam and is very nervous, and Grandpa Libero thinks it's Gianluca's fault. Guido and Carlotta continue their relationship, even though the breakup puts a strain on their relationship. Grandpa Libero hears the news on the news that a young blonde student has been arrested in Fiumicino along with Gianluca for drug dealing. Thinking it's Maria, he feels ill and suffers a heart attack.

Grandpa Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too quiet, and Antoinette doesn't understand why, so Grandpa Libero invites her to take him to the local health authority so Guido can examine him. A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation quickly escalates, verging on disaster.

Cettina sets out to find Giacinto, discovering a bitter truth. Maria, due to a painful experience, no longer wants to take her medical tests. Will Guido be able to convince her otherwise? Nilde is forced to close the restaurant due to a poisoning and notices that Guido is the one signing the complaint. Alberto, improvising a late-night radio show, manages to get a permanent job.

Alice is very anxious about the arrival of the twins, and fills the family with advice and reading manuals on birth. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Nonno Libero packs his suitcase and leaves home due to the constant quarrels of his two children, who find him in a rest home. Until he learns that he has been appointed condominium administrator.

"Pisticca" apologizes to Adriano, but will he be able to make up for it? To escape Carmelo, a very insistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to stay alone for a while?

A great job opportunity for Alice is ruined when contractions begin. Meanwhile, Lele is in the hospital where Giorgi died from post-operative rejection... Will he make it in time for the twins' birth?

Grandpa Libero packs his bags and leaves home due to his two children's constant arguments, ending up in a nursing home. Until he learns he's been appointed building manager. Nilde wants Lele to go into the delivery room, but the next day Lele wakes up late and arrives at the hospital after his sister has already given birth, to a surprising black baby boy.

Lele and Alice are finally married, but as they're leaving for their honeymoon, she has a miscarriage, unaware she's pregnant. Their plans change dramatically. Maria and Reby have a great idea: have their friends play music in the garage! Will they manage to get Lele's permission? Giacinto plans to quit his job as a security guard and open a shop. Will Cettina allow it?

Alice spends more and more time at Casa Martini. Alberto feels responsible for the accident that left his friend Adriano disabled, but thanks to his uncle's help, he finds the strength to visit him in the hospital. Lele and Alice have decided to get married and are looking for a place for their honeymoon together. Everyone helps them find it, but each has their own opinion, and in the end they decide to make do on their own.

Libero wants Lele to marry Alice, but his son doesn't feel ready yet. Er Pasticca, a friend of Alberto's, asks him to deliver some pills, but they end up in Annuccia's hands. Alice has planned a romantic weekend with Lele, but he has to go to a conference in Turin. Among the colleagues will be an old friend of Lele's, of whom Alice is terribly jealous.

Lele and Alice spend the evening together to celebrate their departure, but he is unable to confess what he feels. But when she finds out from François that Alice is in love with him, she decides it's time to come out.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But the situation takes a turn for the worse: the boy shows too much insistence, until he becomes violent. But someone is ready to intervene.

Lele finds a pregnancy test in Irene's locker, and hopes for the arrival of a child. But things are not like that, and indeed Irene was taken to a clinic in Milan. This changes everything on the table.

Alice gives Maria tickets for the Backstreet Boys concert, but a worried Lele doesn't want to give her permission. Luckily grandfather Libero intervenes!

Nonno Libero has organized a show with Orietta Berti, but it would appear to be a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to reach the Martini house.

While Lele and Irene spend the weekend in Bologna, the new neighbors arrive, with whom Ciccio has some problems. Meanwhile Cettina argues with Alberto because of his snobbish friends.

Irene, due to the expiry of her contract with the Asl of Rome, has to ask for a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

Lele and Irene argue after the latter discovers that Lele spent the night with Alice during their wedding in Milan; Irene is involved in a road accident, while Nonno Libero's motorbike is stolen.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But things go haywire: the boy becomes too insistent, to the point of becoming violent. But someone is ready to intervene. Grandma Enrica returns from Ponza with news: she's fallen in love with the owner of a fruit and vegetable supermarket, whom Alice doesn't like. Meanwhile, Lele decides to buy a ring.

Alice gives Maria tickets to the Backstreet Boys concert, but Lele, worried, refuses to let her. Luckily, Grandpa Libero intervenes! Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile, Jessica and Lele go to Ricky, who has woken up, but there's a nasty surprise lurking.

While Lele and Irene spend the weekend in Bologna, their new neighbors arrive, with whom Ciccio is having some problems. Meanwhile, Cettina argues with Alberto over his snobbish friends. At the Martini house, it seems like a maniac is stalking Cettina, but in reality it's just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority, apparently interested in Lele.

While Lele and Irene browse the stalls at the neighborhood festival, where Libero, Giulio, and Giacinto are also selling modern antiques, the Martinis' house catches fire. Lele is very worried: the insurance, having expired, doesn't cover the renovation costs of the burned house, and Ciccio confesses to having started the fire by playing with firecrackers.

The Martini family moves to Poggio Fiorito, a residential area on the outskirts of Rome. Lele faces all the problems that the move entails. Luckily, his sister-in-law, Alice, is there to help him. The family's new housekeeper, Cetinka, causes chaos: as soon as she's hired, some money goes missing, and suspicion falls on her. But could this really be true? And are we sure she's from Poland?

Due to a sudden flood in his home, Giulio finds temporary shelter at the Martini house. Lele is obviously happy to lend a hand to his best friend... but only up to a point. Alice convinces Lele to sign up for a tango class with her. Sparks fly between them and they realize they're attracted to each other. But just then, Sergio, Alice's ex, arrives.

Sergio and Alice set a wedding date. At the Martini household, no one is happy about Alice getting married, and they're right: one evening, in fact, after returning home drunk, Sergio savagely beats Alice. Alice's wedding is annulled: fortunately, she has truly seen who she's dealing with. So, distraught, she moves into the Martini household. Meanwhile, an old flame of Lele's arrives at the clinic.

Great jealousy swirls in the air: Irene is angry with Lele because no doctor at the local health authority can resist his advances, while Maria is dealing with her first heartbreak. Not all the flirtations are welcome. Grandpa Libero tries to contain Marite's advances, while Alice must curb the editor-in-chief's "attentions." A surprise ending to Irene's birthday party.

Ciccio wears a hat lent to him by his girlfriend Susy, but it's full of lice, and the whole family becomes infected. Meanwhile, Alice and Giulio plan a night out, but it turns out to be a disaster. Lele and Irene argue after Irene discovers that Lele spent the night with Alice during the wedding in Milan; Irene is involved in a car accident, while Grandpa Libero's motorcycle is stolen.

Alberto hopes his mother has finally found the man of her life. Unfortunately, she has decided to resume her relationship with her ex-husband, which leads to a heated argument with her son. Alberto will remain at the Martini home. Irene, due to the expiration of her contract with the Rome Local Health Authority, must request a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

A group of children from an orphanage arrive at the clinic for vaccinations. Among them is Robertino, a boy with Down's syndrome who mistakes Lele for Santa Claus and asks him for a new bus for the orphanage as a Christmas gift. Grandpa Libero has organized a show with Orietta Berti, but it looks like a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to arrive at the Martini house.

Ciccio steals from Grandpa Libero's wallet and, along with his friend Filiberto, skips school to go to the mall. But there, the two are threatened by other kids, who force them to give up the money. Lele finds a pregnancy test in Irene's locker and hopes for a child. But things aren't going to be like that, and in fact, Irene has been arrested at a doctor's office in Milan. This changes everything.

Alice meets François, a doctor and friend of Giulio's who helps find families to take in African children for a while, and she decides to go with him to make a reportage. And Lele?

A new doctor arrives at the ASL: Doctor Oscar Nobili. One day a shot is heard from the newcomer's room, it is a man who is trying to commit suicide in front of Oscar. Lele will discover a secret.

Lele is very worried: the insurance, which has expired, does not cover the costs for the renovation of the burnt house and Ciccio confesses that he caused the fire by playing with firecrackers.

Grandpa Nicola finally returns from Brazil, and Nonna Enrica decides to peek into his suitcase, discovering a beautiful necklace. The bad surprise, however, is that her husband returned three days before her: he lied to her!

At the Martini house, it seems that a maniac is pursuing Cettina, in reality it is just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority and seems interested in Lele.

Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile Jessica and Lele go to Ricky who has awakened, but there is a nasty surprise lurking.

Maria heard the news of Leonardo Di Caprio's arrival in Rome to shoot a film and goes to Cinecittà, where she meets Johnny, the bodyguard, and develops a crush on him. Meanwhile Giulio decides to leave for Africa.

Grandma Enrica returns from Ponza with some news, she has fallen in love with the owner of a fruit and vegetable supermarket that Alice doesn't see kindly. Meanwhile Lele decides to buy a ring.

Lele is eager to see Alice again after her declaration at the airport, but a letter she sent seems to cast a shadow over the future of their relationship. What will happen? Lele goes to the airport for Alice's arrival, but in his place arrives a woman Alice met in Africa and to whom she gave her ticket. The two lovers still have to wait, but what will happen when the time comes?

Cettina asks Giacinto to meet to clarify their situation, but he doesn't show up after being stabbed. Cettina can't know this and assumes her ex deliberately didn't show up. While at Alice's house, Lele learns that his girlfriend has been receiving calls from a manic admirer for several weeks, and he doesn't seem to want to stop there.

As preparations for Lele and Alice's wedding are underway, Alice is plagued by doubts. Lele finds a letter in which she expresses her confusion and wishes to think things over, far from him.

"Pasticca" apologizes to Adriano, but will she be able to earn forgiveness? To escape Carmelo, a very persistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to get some alone time?

Alice and Lele announce the gender of their unborn children to their family: a boy and a girl, but the happiness isn't shared by the entire family because Annuccia becomes jealous. Alice is very anxious about the arrival of the twins, and bombards the family with advice and readings from birth manuals. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Lele and Alice are finally married, but while they are leaving for their honeymoon, the woman has a miscarriage, not even knowing she is pregnant. Plans change dramatically.

Alice feels bad all the time and already a few people tell her that the symptoms are all there and that she could be pregnant. Instead, Lele fears that it is something serious.

Nilde wants Lele to enter the delivery room, but the next day Lele wakes up late and arrives at the hospital when her sister has already given birth, by surprise, to a black baby.

Alice tries to help Maria who is facing a particular moment in her life: Roberto has asked her to make love with him, but the girl doesn't feel ready for such an important step, even if telling her is difficult.

Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. At university, Maria meets Guido, a brilliant doctor who is looking for a place to live and will be hired by the new director of the local health authority. Maria is fascinated by Guido, but the doctor seems completely uninterested in her. Meanwhile, Ciccio, after a prank that nearly ended in tragedy, attempts to escape from Lele in Australia.

A new nutritionist, Carlotta, arrives at the local health authority. Her obsessive and aloof behavior fails to win her affection, and misunderstandings and disagreements arise between her and Guido. Until something brings them together again.

Carlotta confesses to Guido that she's in love with him, sending him into a crisis because he can't understand his feelings for Maria. Their birthday dinner, however, is cancelled due to an unexpected event. Maria is delighted to have met Gianluca, a charming lawyer who courts her like a true princess. Meanwhile, at Ciccio's school, some kids break in at night and break the pipes to skip tests and homework.

Meanwhile, Guido is having problems with Carlotta, who's fed up with seeing her boyfriend completely absorbed in the Martini family. Maria sees Gianluca in front of her house, telling her he wants to run away to avoid the trial. Guido and Carlotta are increasingly at odds, and they argue again during dinner. Guido goes to a friend's house, who introduces him to two girls, and the next morning, the doctor wakes up drunk next to one of them.

Maria and Guido go to the beach to be alone, and when they return home, covered in sand, Libero realizes they spent the afternoon together. Due to a mistake, Guido is suspended from the local health authority. Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that everyone already knew. Meanwhile, Guido makes house calls, and patients show up at the Martini house because they want only him.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

There's a lot of news in the Martini household: Maria and Guido have been engaged for two years, and Guido travels back and forth between Rome and Milan. Ciccio still plays rugby and is engaged to an English girl named Emma and... Grandpa Libero is called to school because Annuccia wrote a decidedly strange essay about family. Maria rents a house for herself and Guido, but discovers that, for now, he's forced to stay in Milan.

Among friends and family, Guido and Maria can't find a moment of peace at home, and this certainly isn't good for the couple. Grandpa Libero, however, due to a series of misunderstandings, thinks Ciccio is taking drugs. Grandpa Nicola makes a grand comeback, but the reality is very different from what he pretends. He invites Maria on a cruise, and she, who initially refuses, eventually realizes that all her grandfather has left is family affection.

Maria has returned from her cruise, and Guido immediately showers her with affection, so much so that the entire Martini family catches them soaking in the hot tub. Meanwhile, Cettina has a truly horrifying experience. Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the local health authority. But the troubles aren't over: her scooter doesn't work, and it's a race against time.

Libero writes a letter and gives it to Enrica, asking her to pass it on to Lele in case he dies. Then they both go to the town hall to sign the wedding papers and ask to get married as soon as possible. The local health authority (ASL) is in danger of closing, and all the doctors organize a sit-in protest, which proves futile. Guido, however, decides to request a return to Milan, since staying in Rome no longer makes sense to him.

Guido and Maria are back together and are stronger and happier than before, but he doesn't want Maria to leave for Nigeria. He also has a very important proposal in store. After three years away, Lele returns to the Martini household, finding the situation more than a little unsettling. Thanks to Grandpa Libero's help, Lele will finally be able to become a full-fledged family man again.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

Lele has moved to Paris, along with Alice and the twins. Guido is still in Africa with Maria. Meanwhile, Dr. Emilio Villari arrives at the Martini household, in Rome to open a new private clinic. Alberto returns to live with the Martini household, and the family realizes his relationship is over. Cettina continues to be overprotective of her son Eros, to the point of being unable to bear the thought of sending him to kindergarten.

Torellhonor is on the verge of bankruptcy. Meanwhile, Sarita and Emilio, after convincing an Indian couple not to have an abortion, decide to open a counseling center for non-EU women. Cettina is forced to remove Eros from the expensive private daycare center and place him in a public one. Alberto discovers that his father has cancer and only has a few months to live.

Sarita accepts Emilio's marriage proposal, but Indian tradition dictates that the groom go to the bride with his parents and ask her family for her hand in marriage. Libero and Enrica offer to accompany him. Sarita tries to convince Kabir to accept Emilio, but he is opposed, as he values ​​respecting tradition. Sarita then decides to leave home and go to live with the Martinis.

Maria falls ill with mumps and can no longer defend her thesis, so to avoid the girl waiting another three months, she can't wait to return to Africa with Guido. To resolve the situation, the family comes up with a plan.

Big party at Indian restaurant. Ciccio, Annuccia, Saju, Sarita and Maria offer themselves as dancers and enliven the evening. Maria is elected "Queen of the party" and finally confides her secret to Sarita.

Sarita accepts Emilio's marriage proposal, but Indian tradition requires the groom to go to the bride with his parents and ask her family for her hand. Libero and Enrica offer to accompany him.

To save the clinic, Emilio proposes to buy it with colleagues and patients, all becoming owners of a small share. Meanwhile, stag/hen parties are organized for future spouses.

Ravi gives the girl a letter from his father, written 25 years earlier, in which he claims to have promised his daughter in marriage to repay him for a theft. She refuses to marry him, so Ravi orders her to pay off her debt.

Many returns to Casa Martini: Guido has returned from his experience in Africa, Lele returns with his twins. Cettina and her family are absent: the Martini family's former housekeeper has apparently disappeared in a shipwreck. A nasty surprise awaits Guido and Maria: they discover that their apartment's tenant refuses to return the keys. During a chat, Grandpa Libero reveals to Lele that he's feeling the weight of old age.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile, Guido resists the idea of ​​starting a relationship with his newly reunited mother. Fanny discovers toxic waste dumped in a river. Guido and Ave have a tough confrontation, and Ave increasingly feels the pain of not being there when they needed her. Giulio wins the lottery, and an unexpected snowfall in Poggiofiorito brightens Christmas Day.

The twins notice the silhouette of a woman behind the window of the Torello house and believe it to be Cettina's ghost. Grandma Enrica, with her friends, organizes a séance to summon her. A friend of Annuccia's surprises Fanny and Lele. Annuccia, after finding out from her friend, is reluctant to accept her father's new girlfriend, unlike the rest of the family, who are still somewhat confused.

Lele discovers that Fanny's tests were switched, meaning she isn't pregnant. The two decide to break up, and Lele can now live with Bianca, but Bianca is about to return to the Netherlands. The Martini family is summoned by the police because an American woman is asking for them. The Martinis discover that the woman is actually Cettina, although she seems to remember nothing of her past.

Guido tries to win Maria back, but when she seems to have forgiven him, she sends him a request for separation. Lele intends to stay in Rome forever and announces this to his family, who are thrilled. Grandpa Libero and Ciccio's double wedding is approaching, and preparations are in full swing. Maria and Guido must meet with their lawyer for a preliminary meeting to discuss the separation. But will it be the right choice?

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

Three years have passed since Guido's death, and the time has come for Maria to start over, even romantically. Meanwhile, Lele asks Bianca to take the plunge, but he discovers she's still married to her ex-husband. Bianca is determined to divorce him so she can marry Lele, who has since reunited with an old acquaintance, Virginia, while researching a rare disease. Furthermore, Annuccia faces trouble.

The Martini children are being bullied at school. When Lele and Bianca discover the situation, they convince the children to report the incident to their teacher. Bobò will be the one to demonstrate all the necessary courage. Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco expose a clandestine gambling den.

Lele, due to the presentation of the research for the drug he's working on, is spending more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor. Maria feels guilty for not having devoted enough time to Marco lately. But when he shows up unexpectedly at her house, she'll be the one left speechless.

A ministry inspector comes to inspect the clinic after Virginia chooses to administer a drug not yet authorized. Marco receives an unexpected phone call and learns he must leave for Venice. Everything between Maria and Marco is going swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce from Gus at a crucial moment in their relationship.

At the Martini household, preparations are in full swing for Lele and Bianca's wedding. Little Palù is tasked with bringing photos of her parents to school, and Maria helps her daughter cope with the grief of Guido's passing. The big day has arrived, and everyone is ready to head to Ovindoli for Lele and Bianca's wedding. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.

An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.

The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.

At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.

The situation is critical for the Martinis. Really risking losing their house, Grandpa Libero sets out to track down the builder who defrauded them. For Grandpa Libero, losing his home is such a serious threat that it's even affecting his health. After his reluctance to sell used items at the neighborhood flea market, the family convinces him that everything is fine.

Lele and Bianca discuss the matter and believe it's necessary to fire the gardener, who has been tending the villa's garden for years. However, Melina, overhearing the conversation, believes she'll be the one to be fired. So she immediately gets to work. Marco returns to Rome, and Maria picks him up at the airport. Unexpectedly, his colleague Antonia is also with him. Lying to his girlfriend once again, Marco manages to get away with it, but Maria begins to suspect him.

Things between Marco and Maria seem to be getting worse and worse, so much so that he returns home early in the morning to make the children believe he's still living with them. Grandpa Libero notices the situation and promises to help him. Seeing her father's increasingly sad state, Inge decides to arrange a meeting with the separated mother of a schoolmate. However, the date goes sour, and the woman goes into anaphylactic shock.

Marco and Maria announce to their children that when they return from the school camp, they will each go their separate ways. At this point, Maria can focus on Roberto and introduce him to the family. While Maria is driving to her daughter's camp, her car breaks down. She decides to call Roberto, but just then Marco arrives and offers to drive her.

Marco returns to Rome and Maria is waiting for him at the airport, but only to inform him that it is definitely over between them. Both back home, the situation seems to improve: but how long will it last?

Maria seems more than ever willing to embark on a relationship with Roberto, however continuing to hide everything from Marco, who begins to suspect.

Marco and Maria with the help of the family manage to convince the assistant. Everything could be resolved, were it not for the fact that Micol threatens them: if the wedding doesn't take place, she will do everything to get the baby back.

Lele helps Maria clear her head and the young woman understands that her heart actually beats for Marco. Unfortunately Roberto's father is on the brink of bankruptcy and Maria doesn't feel like leaving him now.

As they are about to cut off electricity and gas at the Martini house, the family decides to leave before everything ends before their eyes. But there's still time to plan a surprise wedding for Maria.

Maria and Marco are busy preparing for the wedding of his younger sister, Sara, who is arriving from America. Grandpa Libero and Enrica are also awaiting the arrival of Lorenzo, a surgeon and Libero's nephew. Sara reveals to her brother Marco that she will no longer run competitively. By making up a lie, she covers up the truth: Sara, in fact, also suffers from heart problems. Meanwhile, her wedding gifts are sent back.

Grandpa Libero and Grandma Enrica are busy getting Palù and Jonathan vaccinated at the clinic. Stefano takes Sara to his country estate, and the two become very close. Lorenzo is running with Sara, who, overdoing it, ends up feeling ill, given her heart problems. Grandma Enrica and Ave convince Grandpa Libero to go on a diet and take an oriental gymnastics class.

Marco and Maria discover the whereabouts of Giada's little brother, Daniel. His parents agree on one condition: Daniel must not know that Giada is his sister, nor that he was adopted. Thanks to Maria's help, Giada manages to meet her brother, Daniel. They immediately connect, even though the little boy doesn't recognize his sister. Lorenzo, on the other hand, is very nervous about the operation he has to perform.

Lorenzo takes his wife to the mountains, to the Majella, to spend time together. But during their vacation, Lorenzo is forced to reveal to Veronica about the night he spent with Sara. Maria can't bring herself to tell Marco she's pregnant, but the situation becomes increasingly exasperating until she is forced to come clean.

A little girl finds Sara unconscious on the beach. She calls Lorenzo on her cell phone, who rushes to her and, after resuscitating her, takes her to Villa Aurora. While Grandpa Libero, Grandma Enrica, and Ave pray for Sara's recovery after the surgery, Lorenzo finds a television on which he can watch a video recorded by Sara before the operation.

Sara and Stefano take Marco home, but the latter doesn't remember anything and has also lost his wedding ring. For this, her sister and her boyfriend decide to investigate. Tommy draws a mural dedicating it to Giada.

Lorenzo takes his wife to the mountains, on the Majella, to spend time together. But, during the vacation, Lorenzo will be forced to reveal to Veronica about the night spent with Sara.

Lorenzo and Sara have finally decided to force fate and get together. For this, the young man decides to leave for America and reveal everything to his wife.