Jake and Anna end up so far back that you hardly know what time it is. In the New Stone Age, people have just started living in villages together and because they have a poor grasp of hygiene and what infections animals and people can spread to each other, the children and the villagers suffer from whipworm infection. The village shaman does his best to cure tired and malnourished Anna and Jake with the help of song, dance and power animals. But does it really help with the nasty infection?

It is poor and scarce in Småland when the year is 1869. So Erik decides to take Lea and Max and Grandma to the "land of the future" USA. Unfortunately, the disease measles strikes and prevents them from traveling. And instead, Erik has to do his best to cure the two children with licorice roots, earth spit cream and dead spirits. Will they survive the nasty virus? And how will it go for grandma?

In the middle of a midsummer celebration in the year 1544, Anna and Jake accidentally poison themselves and an entire village with poisonous flour, and everyone who participates in the celebration suffers from draft sickness. With terrible symptoms such as itchy rashes, tingling in the body and hallucinations, it is not easy for the doctor of the time, the barber, to get the children to crawl again. Will they make it out alive? And is it perhaps that Anna is a witch?

On a nice car trip with coffee and a bath in 1950s Sweden, Emmi and Mario are exposed to the dreaded polio virus and become paralyzed. At the doctor's, they are forced to drink coffee and are subjected to electric shocks and water gymnastics without visible improvement. Will Emmi and Mario survive the dreaded epidemic?

Emmi and Max end up at a party with Queen Kristina herself when the year is 1650. There is a lot of feasting among the upper class at this time and Max and Emmi are treated to everything from fried turkey to pike sausage. After far too many goodies, they unfortunately suffer from gout and suffer from aging and swelling and bad bumps on their hands. Doctors of the time, called city doctors, try to cure the children with, among other things, urine, a bloody ax and a dog! Will these drugs be able to save Emmi and Max?

Life in the country is anything but easy when the year is 1793. Max and Mario have to work hard milking cows, picking eggs and shoveling poo all day! They hardly get anything to eat and drink and as if that wasn't enough, they have the misfortune of getting jaundice. The "wise man's" attempts to cure them don't seem to be the most successful so the big question is: how will our guinea pigs fare?

The year is 1834 and Nouveline and Mario have just moved from the country to the big city of Stockholm. Unfortunately, the nasty disease cholera is ravaging the town and Nouveline and Mario quickly fall ill. The doctor tries to cure them with everything from pig's feet and herbs to blood-sucking leeches, but the question is whether Nouveline and Mario will survive?

In the 13th century, it is the church that decides most things in Swedish society, and it is precisely during a church visit that Anna and Max find out that they have been affected by leprosy. With large boils on their faces and a warning leprosy bell around their waists, Anna and Max are relegated to isolation in a leper colony. Will it make them healthy again?

In the 18th century, many battles are fought at sea and Sixten and Mario are kidnapped to become part of the crew of a warship. On the boat they are forced to work hard and after a few years both Sixten and Mario develop the fatal disease scurvy. Despite bleeding wounds and breathing difficulties, Sixten and Mario are forced to stay and work on the boat. Will it be their death?

The year is 1918 and Isabelle and Max visit a theater hoping to be entertained. Well, they get it, when the entire staff is sick and they instead get infected with the super-dangerous flu, the Spanish flu. Isabelle and Max receive care from stressed-out staff in an overcrowded hospital, and although they get to try several very special remedies, the future does not look very bright.

Because they live in a dark cabin in 19th-century Småland, Anna and Sixten suffer from the deficiency disease rickets. Their bones soften and their bodies are deformed, and it becomes difficult to both walk and eat. Even though Anna and Sixten receive help from a "wise old woman" who does her utmost to cure the children with everything from tree running to cross-country skiing, it is very uncertain whether Anna and Sixten will survive?

In 1741, Isabelle and Mario enjoy themselves at a fancy masquerade ball together with the nobility, but unfortunately they get smallpox. At this time, the doctors have no idea how to cure smallpox so Isabelle and Mario have to put make-up over their large boils in an attempt to look healthy. Does it help or hinder them in the fight against the deadly disease?