What we touch. What we smell. What we feel. They’re all part of our reality. But what if life as we know it reflects only one side of the full story? Some of the world’s leading physicists think that this may be the case. They believe that our reality is a projection—sort of like a hologram—of laws and processes that exist on a thin surface surrounding us at the edge of the universe.

Ninety years after the historic double-slit experiment, the quantum revolution shows no sign of slowing. Join a vibrant conversation with renowned leaders in theoretical physics, quantum computation, and philosophical foundations, focused on how quantum physics continues to impact understanding on issues profound and practical, from the edge of black holes and the fibers of spacetime to teleportation and the future of computers.

For every cell in your body, there's another tiny single-celled creature that also calls your body home. Far from being germs we should eradicate, these ancient friends allow us to digest food, breathe air, and fight off disease. They were here long before us and will undoubtedly remain long after we're gone. They are our microbiome, and after eons of cohabitation, we are finally getting to know one another better. Of course, we aren't always the best of neighbors. Autoimmune diseases, allergies, depression, and Alzheimer's may be diseases of an unhappy microbiome

We have fallen woefully behind in the race to keep up with harmful bacteria as they continually evolve to outsmart our antibiotics; in fact, there are already superbugs we cannot defeat. Predictions are by 2050 there will be more deaths from infections than from cancer if we don't solve this crisis. Join immunologists, biologists, and infectious disease specialists to explore some exciting new tools that may be our salvation in the battle against superbugs.

Are there limits to the human lifespan? Is it possible to stop the process of aging? On average, humans now live far longer than at any point in our history thanks to science and technology. On the horizon, advances in new drugs and medical techniques promise a revolution in how we live, age and die. But these advances may come at a steep cost. In this program, experts explore future challenges while debating the ramifications of an immortal society.

You exist. You shouldn’t. Stars and galaxies and planets exist. They shouldn’t. The nascent universe contained equal parts matter and antimatter that should have instantly obliterated each other, turning the Big Bang into the Big Fizzle. And yet, here we are: flesh, blood, stars, moons, sky. Why? Come join us as we dive deep down the rabbit hole of solving the mystery of the missing antimatter.

Stuff happens. The weather forecast says it’s sunny, but you just got drenched. You got a flu shot—but you’re sick in bed with the flu. Your best friend from Boston met your other best friend from San Francisco. Coincidentally. What are the odds? Risk, probability, chance, coincidence—they play a significant role in the way we make decisions about health, education, relationships, and money. But where does this data come from and what does it really mean?

Scientists are now finally discovering what thinkers, musicians, or even any of us with a Spotify account and a set of headphones could have told you on instinct: music lights up multiple corners of the brain, strengthening our neural networks, firing up memory and emotion, and showing us what it means to be human. In fact, music is as essential to being human as language and may even predate it. Can music also repair broken networks, restore memory, and strengthen the brain?

Nearly every group has its extreme outliers. Where does fundamentalism come from? How does the most powerful organ in the known universe, the human brain, make emotionally driven decisions that ignore reason and fact? In this program, scientists look for answers to why our species may have evolved to accommodate the set of behaviors we associate with zealotry.

The multiverse hypothesis, suggesting that our universe is but one of perhaps infinitely many, speaks to the very nature of reality. Join physicist Brian Greene, cosmologists Alan Guth and Andrei Linde, and philosopher Nick Bostrom as they discuss and debate this controversial implication of forefront research and explore its potential for redefining the cosmic order. Moderated by Robert Krulwich and featuring an original musical interlude, inspired by parallel worlds, by DJ Spooky.

A new generation of technology is revolutionizing neuroscience, allowing a closer study of the brain than had ever seemed possible. The techniques are hybrids of optics, genetics, and synthetic biology with the ability to manipulate brain activity, often in real time. Through direct stimulation of neural connections, some of these techniques hold the promise for the treatment of diseases like depression or schizophrenia.

If we want to discover alien life out there in the universe, we first need to figure out where to look-and what we're even looking for. Will it be biological like us? Could it be artificial, or take some other form we haven't yet considered? And how do we find something so fundamentally different from ourselves? In this program, scientists devise plans for searching for beings beyond Earth while they grapple with the very definition of life.

With ever more refined techniques for measuring complex brain activity, scientists are challenging the understanding of thought, memory and emotion-what we have traditionally called "the self." How do electrical and chemical currents translate to self-awareness? And why does the brain produce consciousness at all? Join a discussion among eminent neuroscientists, philosophers and psychologists who are redefining what it means to be human.

Computers are getting smarter and more creative, offering spectacular possibilities to improve the human condition. There's a call to redefine Artificial Intelligence as Augmented Intelligence, to emphasize the potential of humans working with AI as opposed to being replaced by AI. In this program, AI experts, data scientists, engineers, and ethicists explore how we can work alongside machines, when we should trust machines to make cognitive decisions, and how all of society can benefit from the productive and financial gains promised by advances in AI.