Stephen has highly aggressive jaw cancer and undergoes ground-breaking surgery to save his life. Hilary is suffering from a rare carcinoid tumour and faces a complex procedure with a 40% risk of death.

Following a liver transplant, an operation to remove a rare cancer of the soft palette, and a particularly nasty open fracture of a woman's lower leg.

If surgeons don't operate on Pratyush soon, his tumour could push him into a coma, before killing him. Mariella needs a ground-breaking procedure for a recurring bowel cancer.

Laura, 29, has an incurable brain tumour. To extend her life, she needs it removed. But the hugely risky surgery will have a drastic effect on her memory and may even kill her.

A risky operation on a 66-year-old's massive aortic aneurism, a complicated procedure to remove an angiosarcoma, and an operation which carries a significant risk of facial paralysis.

Gary has a rare tumour lodged in his spine. Leaving it in place will probably lead to paralysis, but an operation carries a huge risk. Margaret has developed a spontaneous hole in her skull.