Surgeons face a challenge as Susan's cancer spreads from her jaw to her eye and nose. Removing it will leave a significant hole in her face, needing complex reconstruction.

Return of the series in which life-saving and life-changing operations involve split-second decisions. Sajid has a massive aneurysm. If it bursts, he will bleed to death.

Gary has a rare tumour lodged in his spine. Leaving it in place will probably lead to paralysis, but an operation carries a huge risk. Margaret has developed a spontaneous hole in her skull.

A risky operation on a 66-year-old's massive aortic aneurism, a complicated procedure to remove an angiosarcoma, and an operation which carries a significant risk of facial paralysis.

TBC

Stephen has highly aggressive jaw cancer and undergoes ground-breaking surgery to save his life. Hilary is suffering from a rare carcinoid tumour and faces a complex procedure with a 40% risk of death.

Following a liver transplant, an operation to remove a rare cancer of the soft palette, and a particularly nasty open fracture of a woman's lower leg.

Laura, 29, has an incurable brain tumour. To extend her life, she needs it removed. But the hugely risky surgery will have a drastic effect on her memory and may even kill her.

Syed's life hangs in the balance as his testicular cancer has spread into his heart. If the tumour dislodges, it could block prove fatal. Consultant urological surgeons undertake a radical plan with the monumental task of removing the tumour, along with help from the cardiac surgeons. In the thoracic theatres, surgeon prepares to operate on 77-year-old David. Last year, David underwent surgery in another hospital to remove cancer from his rib, but tests revealed that the disease is growing back. Renal surgeons prepare to perform a life-changing kidney transplant. Mark had his kidneys removed due to kidney disease, leaving him entirely reliant on dialysis to survive. His half-brother James voluntarily undergoes surgery to donate his kidney and give Mark his life back.

An ENT surgeon must operate on Sarah, whose bone tumour is pushing into her skull. Mike, who has pancreatic cancer, has a high-risk but potentially life-saving operation.