Mildred and Ethel end up as room-mates. Ethel is as mean as ever until she discovers that all new students must pass through the gaze of the All-Seeing Eye which looks deep within to find your regretful past and display it for all to see. Convinced Millie can use her unique tallent to cheat her way past the eye, she pretends to let bygones be bygones.

Weirdsister College has a network of pipes and valves installed as a means to absorb excess magical energy to help reduce the Foster's Effect during the week. This excess energy is released on Fridays, so students and staff must refrain from practising magic on Fridays, or the Foster's effect will be exponentially worse. A new professor, Starfinder, fails to heed the warnings. Millie, Cas and Ethel also ignore these warnings to near disastrous effect.

Professor Starfinder is lecturing on animation of objects, giving those objects personality. He is also assembling a research team, for which he has already selected Miss Hallow. When he stumbles upon Millie using her ability to bring a painting to life, he makes her the focus of the research, and Nick Hobbes becomes jealous he has not been selected for the team. He sets out to impress Professor Starfinder by bringing a Gargoyle to life, which then wreaks havoc on the college.

Misery's Café comes under threat of closure when a matter of unpaid rent comes to light. Millie and Cas set out to find the actual property owner, and help save Misery's. Meanwhile, Professor Starfinder is working on time manipulation experiments which cause havoc, but also offer a possible solution to the problem at hand.

Professor Thunderblast casts a spell on her students in order to boost their magical energy, so they can have more with which to practice. Through an "accident" of Ethel, Millie ends up with far too much magical energy, and begins casting spells subconsciously. Dr. Wendle warns Millie to remain in solitary meditation until the effects wear off, but Nick Hobbes has other plans. Meanwhile, Professor Thunderblast agrees to fill in at Misery's for a jazz band who have cancelled at the last minute.

Millie is plagued with romantic dreams of Nick Hobbes. Cas cannot find her dreamcatcher anywhere. The caretaker has quit, and names Hobbes as his reason. When things start to fall apart, Professor Thunderblast threatens Hobbes with expulsion unless he can manage to convince the caretaker to return.

Hearing a plea for help from Dr. Foster, Professor Starfinder leads the students in a location spell and summoning potion to rescue the good doctor. Something appears to go wrong, and they seem to have summoned the wrong person - someone claiming to be a close acquaintance of Dr. Foster.

While conducting a magical experiment with Mildred's cat, something goes wrong which puts the cat's life in grave danger. Mildred becomes despondent and angered over her cat being involved in the experiment without her permission, and she contemplates dropping out of Weirdsister College. Meanwhile, Elaine believes she has the seventh sense, much to Ben's chagrin.

The annual contest is fast approaching! Initially, the unlikely pair of Hobbes and Ethel is formed, but when Hobbes ends up leaving her out of his experiment, Ethel wants payback. Soon, this friendly competition turns into a battle of the sexes, with Ethel proving there is no fury like a Witch scorned!

Enid Nightshade, an old friend of Millie's from Cackle's Academy, arrives at Weirdsister College! However, Enid is a lot different than she used to be, and Mildred gets more than she bargained for. This causes friction between Ethel and even Cas since Enid's arrival coincides with final exams. To make matters worse, Mildred must either give up Tabby or be kicked out of school.

When Professor Shakeshaft is in a deep depression, he reveals to Mildred that it's because he's pining for an old love from the 1600s. He decides to invent a spell to travel back in time to see her again for the first time in centuries. A concerned Mildred decides to accompany the professor in order to keep an eye on him.

Starfinder is experimenting with the Sorcerer's eggs in order to find a way around the Foster's Effect. Hobbes, on the other hand, tries to absorb the negative magical energy from the eggs he has collected, but ends up accidentally freeing the ghostly Whisperer from the walls of Weirdsister College.

Following his magical mishap with the Sorcerer's eggs, Hobbes attempts to open the gates of power under the will of the Whisperer. Unfortunately for both of them, Mildred and her friends are on the case to save the day! Mildred is ready to take down the ultimate evil to save both Weirdsister College and Hobbes.