When a series of rapes take place, the M.O. matches exactly that of recently released William Reedman ( Steve Jacobs ). Trouble is, his alibi is Jane Halifax!

A gritty prison setting sees Jane working with an ex-boyfriend to try and uncover a murderer amongst a group of psychopaths - all convicted of murder. Jane begins to realise that there is an alterior motive for this killing, but what can be even more threatening than anything they have already done? A fire soon sees Jane alone in the prison unit with four dangerous killers.

Told in retrospect, Jane is receiving councilling from her analyst after having killed someone. It is Christmas, Jane is alone, feeling vunerable, stressed, suffering from panic attacks, drinking a little too much and to cap it all, is called in to help investigate the case of a mass murderer who has shot the customers in a country diner. There are few survivors who provide little in the way of clues. One man, Ray Harvey, the local garage mechanic, is their best hope, but he is a reformed alcoholic, who has fallen off the wagon as a result of the shooting. Detective Eric Ringer works with Jane and falls for her. On New Year's Eve, Eric arrives at Jane's apartment, finding her somewhat under the influence of drink. They end up in bed. Afterwards, Jane is at her lowest ebb. She takes Eric's gun and puts it in her mouth - echoing her father's suicide. Shaking her out of her depression is a call from Ray asking for her assistance.

On the tenth anniversary of her father's death, Jane is approached by an old friend of her father. She asks Jane to assess a thirteen year old girl accused of murdering an eight year old.

When gossip colominist for A-list magazine, Simon Laser, walks into a police station claiming that his murdered lover, prominent judge, Harvey Masters, died in his arms, he is treated with suspicion from the start. Not only was Masters seemingly happily married, he was also known for his strong conservative beliefs. Laser claims their affair was kept a secret and that the killer is out to avenge him by killing those closest to him. It is up to forensic psychiatrist Jane Halifax to determine if Laser is telling the truth, or if something more sinister is lurking under the surface.

Jane rushes back from New Zealand where she has been lecturing, for the funeral of her best friend, Dr. Lisa Hardman. Staying to help Lisa's husband with the children and to wind up Lisa's psychiatric practice, she discovers a patient who displays a dangerous obsession with Lisa's family. Jane begins to suspect that Lisa's death was not due to natural causes and when first she, then Lisa's husband, get sick, Jane realises that she is dealing with a serial poisoner.

Jane Halifax, forensic psychiatrist, facing a gruelling cross-examination at a murder trial, is contacted by ex-boyfriend, Owen Tozer, ( Andrew McFarlane ), also a psychiatrist. He has been having an affair with a patient, Cori Neal ( Sophie Lee ) and seeks Jane's assistance. Owen's own mental state takes a downward spiral when a pregnant Cori is murdered in a hit-and-run accident. To make matters worse, the car involved belongs to Owen. With the police hunting Owen as their prime suspect, Jane is torn between working within the law and helping her ex.

While assessing a convicted murderer for the Parole Board, Jane is asked to provide Grief Counseling at an exclusive boys' school where a teacher has suddenly died. When a pupil she is counseling is murdered, Jane works with local detective, Kaz, (John Walton), to uncover a secret society within the school controlled by a dangerous psychopath. As Jane gets closer to the murderer, her own life is in danger, as she unravels a web of deceit, conspiracy and murder.

The return of Jonah Cole (Steve Bisley) adds some light relief into Jane's life, but his increasingly erratic behaviour begins to worry her. Jane finds herself caught up in Jonah's relentless hunt for dirty cops and as the bodies begin to pile up, it looks likely that Jonah is the killer.

Jane becomes the target of an obsessive admirer. At first she dismisses it as trivial, but when his declarations of love turn to threats, she realises that he is deadly serious. Jane's mother is seriously injured while driving Jane's car, her assistant Ari is beaten unconscious, as the stalker succeeds in isolating Jane from those around her. Handling a complex case of infanticide, caring for her mother and dealing with a dangerous erotomaniac who seems to be tracking her every move, Jane is rapidly reaching breaking point.

Jane finds her misquoted criticism of a colleague's release of a mental patient, who murders again, leads to a patient of her own, Peter Donaldson, ( Ben Mendelsohn ), facing the pressure of exposure to an unforgiving public. In an attempt to help him come to terms with the situation, Jane discovers someone who bears a grudge and is dangerously close to driving Peter over the edge.

Rogue cop, Jonah Cole, ( Steve Bisley ), from Sydney comes to town on the hunt for the 'Make-up Killer'. This is a high profile case where the police are under pressure from politicans and the media to get a result. Calling on Jane Halifax to provide a profile of the serial killer, Jane and Jonah initially lock horns in their attempt to catch the culprit. With his acute sense of smell, Jonah recognises a familiar scent that links all the victims. Abrasive and eccentric in his approach, Jonah's obsession to find the killer wins him no friends, but Jane proves to be equally skilled as his work-mate in this deadly and dangerous pursuit.