Cillas must face difficulties from his childhood in order to progress to his goal weight and set an example for his children. Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend Aaron.

Angie enters the most-trying stretch of her weight-loss journey. She finds herself on the brink of homelessness after Dr. Now refuses to keep her in his program unless she submits to drug rehab for substance abuse.

Maja needs weight-loss surgery so she can lose weight, but Dr. Now won't approve her for surgery if she can't overcome getting dumped by her boyfriend Christian without using food to cope. Justin charts a course to be one of Dr. Now's best patients ever.

In order to keep pace with her daughter Charly’s weight loss, Charity must do something she’s never done: find a way to go it alone; try as she might, Teretha finds one too many obstacles in the way of continuing with Dr. Nowzaradan’s program.

The brothers shock Dr. Now with their staggering collective weight loss.

During her second year of weight-loss, Zsalynn is torn between fighting her weight and fighting for her marriage. Christina lets go of the negative influences in her life and is finally able to live the life of a twenty-something.

Chuck starts from scratch during his second year of weight-loss, discovering a promising new relationship. Paula juggles many responsibilities at once, but is it too much to stay on track for her weight-loss goal?

Even after surgery, Lacey's weight loss moves at a glacial pace. She says she wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight. Meanwhile, abandoned in Houston by her cousin, Mercedes and her kids face destitution.

Vianey and Allen have been on a weight loss journey together. But after Allen's surgery is a success and Vianey's is not, the couple struggles to get back on the same page to save their lives.

Holly has come a long way in her weight loss journey, but now she's trying to balance a wedding and skin surgery. Lashanta struggles to lose any weight at all. When a car drives through a wall in her living room, her weight loss is curtailed even more.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos. Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst ... and faces it alone.

Together weighing more than a ton, the Perrio siblings Roshanda, Brandie and Clarence set out to lose weight as a family; the all-for-one approach may be hurting more than it helps when each of them shows signs of heading in the wrong direction after surgery.

Jeanne struggles to care for herself in the aftermath of her dad's death. Brandon strives to get his weight down in order to feel confident when proposing to his girlfriend Tayler and be the man she deserves.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years. Wess is doing great post-surgery, but his next goal is crucial to his success: lymphedema removal.

A year since her weight loss journey began, Janine is still in the 500 and mostly immobile, and now, Dr. Nowzaradan is running out of options to treat her if she can't find a way to control her eating habit and start walking again.

Paul made a promise to his girlfriend that he intends to keep; to ask her to marry him within a year's time. Now he just has to lose about 300 pounds. Carrie needs surgery badly, but she prefers not to change her eating habits.

After getting his surgery canceled and living in his van by the beach, surgery might be the break David has been waiting for his whole life. Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be for the best.

Margaret succeeded in getting surgery, but Dr. Now is dismayed when she and her mom are back to their old ways just a few months later. Megan grows impatient with her own slow, steady weight loss, and if Dr. Now doesn't approve her for surgery soon, she might just quit.

Nathan is shedding pounds and heading back to work as a drama teacher following his weight loss surgery. However, wife and colleague Amber can't seem to do the same as she struggles to qualify for a second surgery to update one she had years ago.

Thederick has lost enough weight to get the giant lymphedema mass removed from his leg, in one of Dr. Now's biggest removals ever. Will he even bother to pursue weight loss surgery after that? Lindsey loses more than weight when she loses her husband to another woman.

As Steven heals from his weight loss surgery his brother Justin finally decides to come to Texas to get the same procedure but his feelings towards Steven immediately begin to sabotage his hopes of surgery.

Weight loss leads to exciting things when Julian and his wife Irma adopt a baby, but fatherhood might distract Julian from his goals. Cindy needs to change her attitude to lose some weight.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight loss journeys; a major life event sends Sarah into depression, and she must pull herself out of it if she wants to keep losing weight.

Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress. And if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.

For Milla Clark, after 3 years & 5 surgeries, success would mean beating the odds, and becoming one of Dr. Nowzaradan's most impressive weight-loss patients ever. Failure would mean slipping back to the bedbound life she swore she'd never return to.