Doc continues to dig into his memory and, now that he has finally met his "sail," he has a clear lead to follow. He has Giulia at his side who, in addition to Andrea's problems, must also think about her career. Meanwhile, a famous travel blogger is admitted to the ward and entrusted to Federico's care. But this encounter is likely to create more than a few problems.

The search for Doc's memory seems to have come to a dead end, but Andrea has found a new "sail": the upcoming choir competition in honor of Mattia. While he tries to convince Agnese to accompany him, in the ward Federico ends up under pressure, and Riccardo is faced with a case that sends him into crisis and pushes his relationship with Martina to the limit.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

The news of Doc's memory upsets the ward's balance: Agnese fears that recovering his memory will destabilize Andrea's new life, while Damiano is worried about the effect this might have on Giulia. Doc, on the other hand, is increasingly elated, although it is not easy to wedge the therapy prescribed for him by Enrico between the thousands of commitments as head physician.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

Carolina, who is suffering from a mysterious illness, is admitted to the ward, triggering a series of conflicts between Andrea and Agnese that they will have to overcome for their daughter's sake. Meanwhile, a flashy influencer attracts the young trainees' attention and Alba cannot disguise her jealousy towards Riccardo.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

A patient sheds light on a secret about Lorenzo's private life that causes a stir throughout the ward. Meanwhile, Gabriel and Elisa must attempt to reconstruct the life of an elderly inpatient who appears not to remember anything about himself, but repeatedly utters a single word.

After finding the medical file on the patient who died because of a mistake, Andrea tries to reconstruct what happened before the shooting that wiped out his memory. Marco, who was responsible for this death, and Agnese are uncooperative. Alba and Riccardo struggle to rebuild their relationship and things also get complicated between Gabriel and Elisa.

Giulia brings Andrea back to the ward for a patient who has asked to be exclusively examined by him and who does not know about his current condition. An error caused by his amnesia puts all the trainees under pressure. Meanwhile, Alba is forced to confront the resentment she feels towards her mother.

Agnese's condition rapidly deteriorates and Andrea receives the support of the whole ward in the attempt to discover what disease she is suffering from. However, the accusations levelled against him regarding his involvement in the falsification of data on pharmaceutical trials risk him having to leave the hospital for good.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the primary.

Andrea finds himself in hot water when a former trainee accuses him of falsifying data from a pharmaceutical trial: unable to defend himself due to his amnesia, he seeks confirmation from people close to him. In the meantime, Lorenzo has to fight to get Chiara on the transplant list and Agnese has a sudden illness.

Engaged in following two cases at the same time to prove that he is up to the primary, Doc is in direct competition with the new primary and takes several risks.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

While a small war breaks out between Doc and the surgeon Valenti because of Carolina, Doc must face the case of a boy with very present parents and is forced to question himself as a father.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

To treat an imprisoned mother, accused of trying to kill her daughter, Doc must fight against the prejudices of the entire hospital, just as he himself is being targeted by the investigation.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.

February 2020. Doc is determined to keep his team together that is falling apart: Giulia will move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia and even Elisa no longer seems interested in the department.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.

While Andrea seems intent on leaving everything, refusing to deal with the difficult case of the nurse Giacomo, a new internist, Damiano Cesconi, and a new infectious disease specialist, Cecilia Tedeschi, arrives in the hospital, but above all a new primary, who seems ready to dismantle the department from the inside.

The deadline to submit the research is approaching, but Giulia seems to have other things on her mind. Even Doc struggles to manage the myriad commitments: there's the meeting with the funders and then there's Carolina, who is in town for a few days. Everything takes a back seat, however, when Lin's sister is hospitalized. A case that will force the resident to come to terms with her father.