Doc continues to dig into his memory and, now that he has finally met his "sail," he has a clear lead to follow. He has Giulia at his side who, in addition to Andrea's problems, must also think about her career. Meanwhile, a famous travel blogger is admitted to the ward and entrusted to Federico's care. But this encounter is likely to create more than a few problems.

The search for Doc's memory seems to have come to a dead end, but Andrea has found a new "sail": the upcoming choir competition in honor of Mattia. While he tries to convince Agnese to accompany him, in the ward Federico ends up under pressure, and Riccardo is faced with a case that sends him into crisis and pushes his relationship with Martina to the limit.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.

The news of Doc's memory upsets the ward's balance: Agnese fears that recovering his memory will destabilize Andrea's new life, while Damiano is worried about the effect this might have on Giulia. Doc, on the other hand, is increasingly elated, although it is not easy to wedge the therapy prescribed for him by Enrico between the thousands of commitments as head physician.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

All the secrets come to light in this special episode, a tribute to the medical heroes of the pandemic.

A violent earthquake sows panic at the Ambrosiano Hospital. Lin is afraid for her family; Ric decides on Laura's proposal; Federico has to perform a surgery for which he does not feel ready; Martina has an encounter that threatens to bring up her secret; Giulia, on the other hand, has to manage the ward because Doc is stuck in an elevator and has to save a pregnant patient.

Doc enters a competition with an AI: if he does not want to be replaced by a machine, he must find the correct diagnosis for a patient before the computer. Martina, on the other hand, is given a case that forces her to come to terms with her conscience, while Agnese is confronted with a terrible decision to protect one of Andrea's secrets.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

Giulia brings Andrea back to the ward for a patient who has asked to be exclusively examined by him and who does not know about his current condition. An error caused by his amnesia puts all the trainees under pressure. Meanwhile, Alba is forced to confront the resentment she feels towards her mother.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.

Andrea finds himself in hot water when a former trainee accuses him of falsifying data from a pharmaceutical trial: unable to defend himself due to his amnesia, he seeks confirmation from people close to him. In the meantime, Lorenzo has to fight to get Chiara on the transplant list and Agnese has a sudden illness.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.

Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the primary.

Engaged in following two cases at the same time to prove that he is up to the primary, Doc is in direct competition with the new primary and takes several risks.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

While a small war breaks out between Doc and the surgeon Valenti because of Carolina, Doc must face the case of a boy with very present parents and is forced to question himself as a father.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

To treat an imprisoned mother, accused of trying to kill her daughter, Doc must fight against the prejudices of the entire hospital, just as he himself is being targeted by the investigation.

February 2020. Doc is determined to keep his team together that is falling apart: Giulia will move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia and even Elisa no longer seems interested in the department.

A train accident turns the Internal Medicine ward into an improvised emergency room. All the doctors are required to do their best to deal with the emergency. One of the wounded is a girl who reopens an important chapter in Riccardo's past that the young man had considered closed forever.

In an attempt to return to his role as a father and to help Carolina recover from her illness, Andrea starts to pursue Agnese again. A bad headache creates problems for Gabriel while treating a patient. Elisa and Riccardo have to deal with an aspiring astronaut.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.